Screening for mobile colistin resistance gene-9 (mcr-9) in multidrug resistant uropathogenic Escherichia coli isolated from patients with urinary tract infections.

ABSTRACT:

Objective

Colistin and Polymyxin B form the reserve group of antibiotics. Resistance to colistin has been increasing across the world including India, posing treatment challenges to clinicians. Use of colistin as a feed supplement in livestock and aquaculture sectors have contributed to the spread of resistance, underlining the need for surveillance among clinical isolates in hospitals. Recently, presence of 10 variants of plasmid-associated mobile colistin resistance (mcr) genes have contributed to colistin resistance in the Gram-negative Enterobacterales. Of these, the mcr-9 is unique in terms of its inducible character in presence of sub-lethal concentrations of colistin, making it clinically relevant. A recent report of mcr-9 from an environmental isolate from Pondicherry promp

SUBMITTER: Lakshmanan D 

PROVIDER: S-EPMC12291223 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature