Optimizing intraoperative radiotherapy as a tumor bed boost with whole-breast irradiation in breast cancer.

ABSTRACT:

Objective

This study aimed to evaluate the safety, efficacy, and optimal dosing of intraoperative radiotherapy (IORT) as a tumor bed boost in combination with whole-breast irradiation (WBI) in individuals with breast cancer in China undergoing breast-conserving surgery (BCS).

Methods

A retrospective analysis was conducted on 217 female patients without metastatic disease who underwent BCS between May 2020 and December 2023 and received INTRABEAM IORT followed by postoperative WBI. Adjuvant therapies were administered as indicated. Evaluated outcomes included recurrence, disease-free survival (DFS), overall survival (OS), wound healing, and the incidence of radiodermatitis.

Results

The cohort ranged in age from 20 to 67 years, with a median age of 48 years. Among them,

SUBMITTER: Chen J 

PROVIDER: S-EPMC12291229 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature