CPAP improves regional lung strain rate and diaphragm velocity of relaxation in experimental self-inflicted lung injury.

ABSTRACT:

Background

Strenuous respiratory effort has been proposed as a second hit in severe acute lung injury (ALI), introducing the concept of "patient self-inflicted lung injury" (P-SILI). In an experimental setting, noninvasive continuous positive airway pressure (CPAP) attenuates lung and diaphragmatic injury, but the underlying mechanisms remains elusive. Here we investigate the effects of noninvasive CPAP on global and regional lung strain and diaphragm velocity of contraction and relaxation in an experimental P-SILI model.

Methods

Lung injury was induced in Sprague Dawley rats through surfactant depletion followed by either three hours of standard oxygen therapy (Control group) or CPAP support (CPAP group). Subjects were assessed through inspiratory and expiratory muscle acti

SUBMITTER: Perez A 

PROVIDER: S-EPMC12291241 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature