Association of novel triglyceride-glucose-related indices with incident stroke in early-stage cardiovascular-kidney-metabolic syndrome.

ABSTRACT:

Background

Emerging triglyceride-glucose (TyG)-related indices, such as the TyG-related body roundness index (TyG-BRI), a body shape index (TyG-ABSI), weight-adjusted waist index (TyG-WWI), and Chinese visceral adiposity index (TyG-CVAI), have gained attention as promising predictors of diverse cardiometabolic conditions. Nevertheless, their prospective associations with stroke onset remain insufficiently characterized, especially in individuals affected by cardiovascular-kidney-metabolic (CKM) syndrome.

Methods

This prospective cohort study included 7,503 middle-aged and older adults with CKM syndrome stages 0-3 (see Methods: Definition of CKM Stages 0 to 4) from the China Health and Retirement Longitudinal Study (CHARLS). Cox proportional hazards models were used to evalua

SUBMITTER: Yue Y 

PROVIDER: S-EPMC12291248 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature