Vaccination as a strategy for Chlamydia trachomatis control: a global mathematical modeling analysis.

ABSTRACT:

Background

Chlamydia trachomatis (CT) is among the most common sexually transmitted infections and is associated with substantial health and economic burdens. Vaccination may offer a promising strategy for its global control.

Methods

A deterministic, age-structured mathematical model was applied to assess the global impact of a hypothetical CT vaccine. The analysis explored a range of assumptions for vaccine efficacy against infection acquisition ( VES ), duration of protection, and coverage, across both adult catch-up and adolescent-targeted vaccination strategies.

Results

Vaccinating individuals aged 15-49 years beginning in 2030 with a vaccine of VES=50% and 20-year protection, scaled to 80% coverage by 2040, reduced global CT prevalence, incidence rate, and annual

SUBMITTER: Makhoul M 

PROVIDER: S-EPMC12291290 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature