Carboranes without Cage Carbons: <i>closo</i>-Dodecaborate Mimics of Neutral <i>closo</i>-Carboranes.

ABSTRACT: Substituted two-dimensional aromatic systems, such as arenes, exhibit well-established reactivity patterns at specific sites, largely due to the pronounced electronic directing effects of attached substituents. In contrast, the regioselectivity of three-dimensional aromatic molecules as a function of substituents remains less understood and documented. In this work, we demonstrate that a series of closo-dodecaborate ([B₁₂H₁₂]^2-) cluster isomers containing two -NMe₃⁺ moieties exhibit unprecedented regioselective reactivity at boron vertices farthest from the charged substituents. Through a combination of theoretical and experimental studies, we reveal that these boron clusters display near-perfect regioselectivity with multiple e

SUBMITTER: Ready AD 

PROVIDER: S-EPMC12291439 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature