Identification of Punicalagin as a Key Bioactive Compound Responsible for the Antimicrobial Properties of <i>Punica granatum</i> L. Peel Extract against <i>Staphylococcus aureus</i>.

ABSTRACT: This study highlights the potential of Punica granatum (pomegranate) peel extract (PPE) as a natural antimicrobial alternative to synthetic chemicals. Pomegranate peels, typically considered a byproduct of fruit processing, contain bioactive compounds such as polyphenols, flavonoids, and tannins. This research explored the antimicrobial efficacy of these phytochemicals against Staphylococcus aureus using a bioassay-guided fractionation approach to identify key bioactive components. While evaluating antimicrobial efficacy is critical, it is equally important to ensure safety for human use. Therefore, we assessed the cytotoxicity of punicalagins α and β on human keratinocytes to determine their biocompatibility and potential for safe application in food or therapeutic settings.

SUBMITTER: Salim A 

PROVIDER: S-EPMC12291446 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature