Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers.

ABSTRACT: Here we report a C₃-symmetric metal-binding tripeptide, BTMA-1, that self-assembles in water into either a chiral supramolecular helical polymer or a discrete Co^II peptide helicate, depending on metal coordination. The Co^II peptide helicate exhibits high affinity and selectivity toward DNA three-way junctions (3WJ), a class of noncanonical DNA structures with emerging biological relevance. Importantly, we demonstrate that the recognition process can be triggered dynamically by adding Co^II ions to a dispersion of the supramolecular polymer, which acts as an inert precursor reservoir in physiological media. In this way, our strategy shows that chiral supramolecular helical polymers can form temporarily inactive aggregates that release discre

SUBMITTER: Alcalde-Ordonez A 

PROVIDER: S-EPMC12291456 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature