Small Molecule Catalyst for Peptide Synthesis.

ABSTRACT: Peptide synthesis is a highly optimized process that has led to the production of new classes of therapeutics and materials. The process of peptide synthesis is straightforward: commercially available, orthogonally protected amino acids can be linked on the solid phase using highly efficient coupling agents. However, the simplicity of peptide synthesis masks a significant drawback of the current method: it is highly wasteful and utilizes a solvent that is facing restrictions on its use. A catalyst that allows solid phase synthesis of peptides in benign solvents without requirement for excess reagents and protected amino acids would have a significant impact. Here, we describe the development of a small molecule catalyst for peptide synthesis. The catalyst design incorporates redox recyclin

SUBMITTER: Panigrahi NR 

PROVIDER: S-EPMC12291467 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature