Monofluoromethyl Radical Mediated Halogen-Atom Transfer.

ABSTRACT: Halogen-atom transfer (XAT) is an effective method for generating carbon radicals from alkyl halides. While stannanes and silanes have shown potential, their toxicity and secondary reactivity necessitate the search for better alternatives. Recently, carbon-based α-amino alkyl radicals have emerged as possible substitutes; however, their generation under photochemical conditions requires the use of photocatalysts. In this work, we present a novel XAT method that eliminates the need for photocatalysts by utilizing the direct excitation of a monofluoroacetoxy ligand-containing hypervalent iodine(III) reagent. This approach allows nucleophilic monofluoromethyl radicals to efficiently form carbon radicals from activated alkyl halides. These radicals can subsequently functionalize unactivated al

SUBMITTER: Ramkumar N 

PROVIDER: S-EPMC12291468 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature