Identification of a moxidectin dose for 4- to 11-year-old children to support registration and potential use for onchocerciasis elimination: results of an open-label pharmacokinetic and safety study.

ABSTRACT:

Background

The WHO and onchocerciasis-endemic countries target elimination of the transmission of Onchocerca volvulus, the parasite causing onchocerciasis, primarily through ivermectin mass drug administration (MDA). In Africa, alternative treatment strategies are required to achieve or accelerate elimination. One of these is the MDA of moxidectin, an anthelmintic drug for which an 8 mg dose to individuals aged 12 years and older has received regulatory approval. This study was conducted to identify dose levels for children aged 4 to 11 years.

Methods

An open-label, non-comparative, single-dose study in an onchocerciasis-endemic area of Ghana was designed to evaluate moxidectin pharmacokinetics and safety in four groups comprising nine individuals each: those aged 12-17 year

SUBMITTER: Opoku NO 

PROVIDER: S-EPMC12291498 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature