The burden of illness in Prader-Willi syndrome: a systematic literature review.

ABSTRACT:

Background

Prader-Willi syndrome (PWS) is a rare, genetic neurobehavioral and metabolic disorder marked by hyperphagia, behavioral challenges, and significant comorbidities, requiring a multidisciplinary approach for effective management. This systematic review aimed to comprehensively evaluate the burden of disease associated with PWS, focusing on mortality, healthcare resource utilization, economic burden, and quality of life.

Methods

The literature search, conducted on August 13, 2024, included the MEDLINE, Embase, and Cochrane Library databases, as well as conference proceedings. Original studies published since 2014 were selected based on relevance to PWS patient burden, covering mortality, humanistic and economic impacts. Data from the selected studies were extracted,

SUBMITTER: Dempsey D 

PROVIDER: S-EPMC12291511 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature