Association of knockdown resistance mutations with pyrethroid resistance in Aedes aegypti, a major arbovirus vector in Cameroon.

ABSTRACT:

Background

The development of insecticide resistance in Aedes mosquitoes has been reported in several African countries. However, information about the mechanisms involved remains scarce. This study aimed to address this issue by updating the resistance profile of A. aegypti and evaluating the role of known knockdown resistance (kdr) mutations in the observed phenotypic resistance in Ae. aegypti in Cameroon.

Methods

Larvae and pupae of Aedes were collected in 2022 in four sites in Cameroon and reared to adulthood. Adult mosquitoes were tested using World Health Organization (WHO) tube bioassays for pyrethroids, bendiocarb and fenitrothion, synergist assays with piperonyl butoxide (PBO) and WHO bottle tests for clothianidin following WHO recommendations. Dead and live mosquit

SUBMITTER: Keumeni CR 

PROVIDER: S-EPMC12291522 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature