Accurate forecasting in acute ischemic stroke: innovative nomogram models for early neurological deterioration and 90-day prognosis outcomes following intravenous thrombolysis.

ABSTRACT:

Purpose

This study aimed to develop novel nomogram models capable of predicting early neurological deterioration (END) and 90-day prognosis outcomes in acute ischemic stroke (AIS) patients treated with IV thrombolysis.

Methods

A retrospective derivation cohort comprising 298 AIS patients was enrolled from January 2021 to March 2024. A separate validation cohort of 94 patients was retrospectively enrolled between April 2024 and December 2024. END was defined as a sustained NIHSS increase of ≥ 2 points within 24 h, and poor prognosis outcome a mRS score of 3-6 at 90 days. Multivariate logistic regression analysis was employed to construct nomogram models for the prediction of outcomes.

Results

In the derivation cohort, 23.83% patients with END experienced a poor 90-day

SUBMITTER: Wei L 

PROVIDER: S-EPMC12291524 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature