Biomimetic Nanoparticles Simultaneously Targeting Modulation of Lipid Metabolism and Phenotype of Macrophages for Programmed Atherosclerosis Management.

ABSTRACT: Atherosclerosis, characterized by dyslipidemia and severe inflammation, has become the main cause of cardiovascular disease. However, accurately and efficiently regulating lipid metabolism and relieving inflammation is a great challenge. Herein, we design a plaque/macrophage dual-targeting programmed atherosclerosis management strategy for synchronously regulating lipid metabolism and the macrophage phenotype. First, the biomimetic nanoparticles (named HA-ML@(H + R) NPs) were constructed by coloading rosuvastatin and hydroxysafflor yellow A into the hyaluronic acid (HA)-modified hybrid macrophage membrane-liposome NPs, enabling them to target plaques and macrophages simultaneously. The in vitro assay indicated that HA-ML@(H + R) NPs exhibited distinguishing antioxidant ability and reversed

SUBMITTER: Dong X 

PROVIDER: S-EPMC12291585 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature