Enhanced Quinolone Resistance and Differential Expression of Efflux Pump <i>nor</i> Genes in <i>Staphylococcus aureus</i> Grown in Platelet Concentrates.

ABSTRACT: Background/Objective: Platelet concentrates (PCs) are used in transfusion medicine to treat bleeding disorders. Staphylococcus aureus, a predominant PC contaminant, has been implicated in several adverse transfusion reactions. The aim of this study was to investigate the impact of PC storage on S. aureus resistance to quinolones, which are commonly used to treat S. aureus infections. Methods/Results: Four transfusion-relevant S. aureus strains (TRSs) were subjected to comparative transcriptome analyses when grown in PCs vs. trypticase soy broth (TSB). Results of these analyses revealed differentially expressed genes involved in antibiotic resistance. Of interest, the norB gene (encodes for the NorB efflux pump, which is implicated in quinolo

SUBMITTER: Paredes C 

PROVIDER: S-EPMC12291658 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature