Prognostic significance of unintentional weight loss in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

While intentional weight loss achieved through cardiometabolic medications has been associated with robust salutary effects in heart failure (HF) with preserved ejection fraction (HFpEF), the clinical significance of unintentional weight loss in this setting remains unclear.

Methods and results

This retrospective cohort study included 434 overweight or obese patients with invasively proven HFpEF (67 ± 11 years, 236 female), without weight-reducing therapies or known malignancy, who underwent invasive hemodynamic cardiopulmonary testing and long-term clinical follow-up. The annualized weight change from index to final evaluation for the tertiles was: -21.1 to -1.8 kg/year (tertile 1); -1.8 to 0 kg/year (tertile 2); and 0 to +17.0 kg/year (tertile 3). Patients in tertile

SUBMITTER: Ibe T 

PROVIDER: S-EPMC12292023 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature