High Co-Expression of <i>GPAT4</i> and <i>SLC7A11</i> as a Predictor of Platinum Resistance and Poor Prognosis in Patients with Epithelial Ovarian Cancer.

ABSTRACT: Background/Objectives: This study aimed to determine whether the expression levels of GPAT4 and SLC7A11 are associated with survival outcomes and platinum resistance in epithelial ovarian cancer (EOC) patients. Methods: We analyzed the medical records of EOC patients. EOC samples obtained during surgery were stained for GPAT4 and SLC7A11. Cox regression and Kaplan-Meier analyses were performed to assess the impact of GPAT4 and SLC7A11 expression on overall survival (OS). Results: We found that GPAT4 and SLC7A11 expression levels were greater in platinum-resistant ovarian cancer tissues than in platinum-sensitive ovarian cancer tissues. High expression of both GPAT4 and SLC7A11 was associated with an

SUBMITTER: Yu P 

PROVIDER: S-EPMC12292186 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature