Transcriptome and Cellular Evidence of Depot-Specific Function in Beef Cattle Intramuscular, Subcutaneous, and Visceral Adipose Tissues.

ABSTRACT: Deposition of intramuscular adipose tissue (IMAT) is the primary determinant for beef quality grade in the U.S. Accumulation of subcutaneous (SCAT) and visceral (VIAT) adipose tissue precedes that of IMAT and often leads to excessive adiposity in beef cattle. Approaches to increase marbling while limiting subcutaneous and visceral adiposity are limited. Our objective is to define the depot-specific transcriptome profile and adipocyte function in IMAT, SCAT, and VIAT in beef steers. Transcriptomics revealed the upregulation of adipogenic and lipogenic genes in SCAT and VIAT vs. IMAT. Functional transcriptome analysis demonstrated the activation of pathways for lipid metabolic processes and biosynthesis in SCAT, accompanied by increased preadipocyte proliferation, adipocyte size, and insulin

SUBMITTER: Tegeler AP 

PROVIDER: S-EPMC12292588 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature