Mn-Doped CeO₂ Nanozyme-Integrated Mesoporous Interfaces for High-Sensitivity Antifouling Electrochemiluminescence Biosensing.

ABSTRACT: To address the challenges of nonspecific adsorption interference and low mass transfer efficiency encountered by electrochemiluminescence (ECL) sensors in complex biological matrices, this study developed a Mn@CeO₂ nanozyme-based sensing interface. The Mn-doped CeO₂ enhanced electron transfer efficiency, increased oxygen vacancy concentration, and stabilized the Mn-O-Ce structure, collectively enabling highly efficient peroxidase (POD)-like activity. The design significantly improved ECL reaction efficiency, which simultaneously conferred synergistic antifouling and mass transport enhancing properties. The mesoporous silica nanoparticle on the sensing interface accelerated mass transfer processes, thereby overcoming the limitations of traditional diffusion-controlled

SUBMITTER: Huang G 

PROVIDER: S-EPMC12293221 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature