Yeast Oral Delivery of DAF16 shRNAs Results in Effective Gene Silencing in <i>C. elegans</i>.

ABSTRACT: Plant Parasitic Nematodes (PPNs) are a major problem in agriculture. Damage caused by PPNs has been estimated at USD 80-157 billion annually. The estimates could be even worse in the future in the context of a growing world population in a climate change scenario and with the removal/reduction in the use of some nematodicides due to the strong ecological impact. Biocontrol Agents (BCAs) currently constitute only 8.8% of the general pesticide market. With a view to an ecological transition, the transition from pesticides to biopesticides represents an important challenge that appears necessary not only for organic farming, but also in so-called integrated agriculture. Among the possible BCAs, microorganisms, and in particular yeast, which enjoys the GRAS (Generally Recognized As Safe) statu

SUBMITTER: Caraba B 

PROVIDER: S-EPMC12293383 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature