Screening of Potential Drug Targets Based on the Genome-Scale Metabolic Network Model of <i>Vibrio parahaemolyticus</i>.

ABSTRACT: Vibrio parahaemolyticus is a pathogenic bacterium widely distributed in marine environments, posing significant threats to aquatic organisms and human health. The overuse and misuse of antibiotics has led to the development of multidrug- and pan-resistant V. parahaemolyticus strains. There is an urgent need for novel antibacterial therapies with innovative mechanisms of action. In this work, a genome-scale metabolic network model (GMSN) of V. parahaemolyticus, named VPA2061, was reconstructed to predict the metabolites that can be explored as potential drug targets for eliminating V. parahaemolyticus infections. The model comprises 2061 reactions and 1812 metabolites. Through essential metabolite analysis and pathogen-host association screening with VPA2061, 10

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12293652 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature