Differential BACH1 Expression in Basal-like Breast Tumors of Black Women Identified via Immunohistochemistry.

ABSTRACT: BACH1 has been identified as a functional regulator of cancer metastasis and metabolic signaling in breast cancer cells. However, the clinical relevance of BACH1 expression in breast tumors remains poorly understood. Using a tissue microarray from a cohort of 130 patients, we assessed the expression of BACH1 and its known target gene, MCT1 (encoded by SLC16A1), through immunohistochemistry (IHC). The expression data were then analyzed in relation to clinical variables, including breast cancer subtypes, tissue types, tumor size and grade, patient racial background, and age group. We found positive associations between BACH1 expression and tumor size, tumor grade, and the basal-like subtype. Importantly, BACH1 expression was significantly higher in tumors from Black women compared to

SUBMITTER: Dowling NM 

PROVIDER: S-EPMC12293708 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature