A Microsphere-Based Sensor for Point-of-Care and Non-Invasive Acetone Detection.

ABSTRACT: Ketones, which are key biomarkers of fat oxidation, are relevant for metabolic health maintenance and disease development, making continuous monitoring essential. In this study, we introduce a novel colorimetric sensor designed for potential continuous acetone detection in biological fluids. The sensor features a polydimethylsiloxane (PDMS) shell that encapsulates a sensitive and specific liquid-core acetone-sensing probe. The microsphere sensors were characterized by evaluating their size, PDMS shell thickness, colorimetric response, and sensitivity under realistic conditions, including 100% relative humidity (RH) and CO₂ interference. The microsphere size and sensor sensitivity can be controlled by modifying the fabrication parameters. Critically, the sensor showed high select

SUBMITTER: Osorio Perez O 

PROVIDER: S-EPMC12293801 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature