The Association of <i>VDR</i>, <i>CYP2R1</i>, and <i>GC</i> Gene Polymorphisms, Dietary Intake, and BMI in Regulating Vitamin D Status.

ABSTRACT: Vitamin D plays a crucial role in bone health and immune function, with serum 25(OH)D levels influenced by genetic, dietary, and metabolic factors.

Background/objectives

This study investigated the impact of VDR rs731236, CYP2R1 rs10741657, and GC rs2282679 polymorphisms, body mass index (BMI), and dietary vitamin D intake on vitamin D status.

Methods

A total of 230 adults were classified into four BMI categories: normal weight (NW), overweight (OW), obesity class I (OB), and obesity class II/III (OP). Participants completed a Food Frequency Questionnaire (FFQ) and a 7-day Food Frequency Diary (FFD). Genotyping was performed using TaqMan assays, and serum 25(OH)D was quantified via spectrophotometry. Statistical analyses included ANOVA and multiple linear

SUBMITTER: Stroia CM 

PROVIDER: S-EPMC12293828 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature