Regulation of Hindbrain Vascular Development by <i>rps20</i> in Zebrafish.

ABSTRACT: During aging, the brain vasculature undergoes significant deterioration characterized by increased arterial tortuosity, compromised blood-brain barrier integrity, and reduced cerebral blood flow, all of which contribute to various neurological disorders. Thus, understanding the mechanisms underlying aging-related cerebrovascular defects is critical for developing strategies to alleviate aging-associated neurological diseases. In this study, we investigated the role of aging-related genes in brain vascular development using zebrafish as an in vivo model. By thoroughly analyzing scRNA-seq datasets of mid- and old-aged brain vascular endothelial cells (human/mouse), we found ribosomal protein S20 (rps20) significantly down-regulated during aging. qPCR analysis and whole-mount in situ h

SUBMITTER: Shen X 

PROVIDER: S-EPMC12293849 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature