Dopamine-Conjugated Methacrylated Gelatin Hydrogel-Physical, Mechanical, and Biological Properties.

ABSTRACT: This study develops and characterizes GelMA-dopamine conjugates as novel tissue adhesives, offering an alternative to sutures. GelMA was synthesized at 5%, 10%, and 15% (w/v) with medium and high dopamine (DOPA) conjugation. Adhesives were evaluated for swelling, degradation, mechanical strength, and cytocompatibility using AlamarBlue assays and F-actin staining to assess cell viability and adhesion. Our findings indicate that DOPA conjugation significantly reduced the swelling ratio while increasing the biodegradation rate, resulting in enhanced release of free methacrylate groups over time. The mechanical properties and adhesion capabilities showed a complex relationship with DOPA substitution. Notably, the formulation containing 10% GelMA with high dopamine conjugation (HD

SUBMITTER: Lu W 

PROVIDER: S-EPMC12294156 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature