Chitosan-Based Hydrogels Containing Nystatin and Propolis as a Novel Tool for <i>Candida auris</i> Skin Decolonization.

ABSTRACT: Candida auris is an emerging multidrug-resistant fungal pathogen with a high affinity for skin colonization and significant potential for nosocomial transmission. This study aimed to develop and evaluate chitosan-based hydrogels loaded with nystatin and propolis as a topical antifungal strategy for skin decolonization of C. auris. The formulations were selected based on our previous results and optimized for cutaneous application. The internal structure of the hydrogels was investigated by polarized light microscopy, confirming the amorphous nature of propolis and the partial dispersion of nystatin. The antifungal activity was assessed against ten fluconazole-resistant C. auris strains. The CS-NYS-PRO1 formulation demonstrated the highest antifungal performance in the

SUBMITTER: Bostanaru-Iliescu AC 

PROVIDER: S-EPMC12294422 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature