A Genome-Wide Association Study of Anti-Mullerian Hormone (AMH) Levels in Samoan Women.

ABSTRACT: Background/Objectives: The anti-Müllerian hormone (AMH) is a key biomarker of the ovarian reserve, correlating with ovarian follicle count, fertility outcomes, and menopause timing. Understanding its genetic determinants has broad implications for female reproductive health. However, prior genome-wide association studies (GWASs) have focused exclusively on women of European ancestry, limiting insights into diverse populations. Methods: We conducted a GWAS to identify genetic loci associated with circulating AMH levels in a sample of 1185 Samoan women from two independently recruited samples. Using a Cox mixed-effects model we accounted for AMH levels below detectable limits and meta-analysed the summary statistics using a fixed-effect model. To prioritize variants and genes,

SUBMITTER: Erdogan-Yildirim Z 

PROVIDER: S-EPMC12294779 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature