A Novel Self-Expanding Transcatheter Mitral Valve with Dual Annulus/Valve Diameter.

ABSTRACT: Background: The development of transcatheter mitral valves (TMVs) represents a major advancement in cardiology, driven in part by the growing elderly population. Elderly patients frequently suffer from secondary mitral regurgitation but are often ineligible for surgical valve replacement due to high procedural risks. This study aimed to develop a self-expanding TMV stent fabricated from a single nitinol tube, featuring two distinct central zones: a smaller-diameter valve-containing segment and a larger-diameter anchoring segment for the mitral annulus. Methods: We used the COMSOL Multiphysics 6.0 software package for biotechnical engineering. Prototypes of stents and valves were manufactured in five sizes following a 22 Fr delivery system compatibility assessment and pulsatil

SUBMITTER: Zhuravleva IY 

PROVIDER: S-EPMC12295116 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature