Optimizing region of interest size and placement for clinical opportunistic CT trabecular bone Hounsfield unit measurements.

ABSTRACT:

Purpose

No formal guidance exists regarding optimal opportunistic computed tomography (CT) region of interest (ROI) size or placement to clinically obtain bone Hounsfield unit (HU) data. Using clinical CT scans, this study evaluated ROI size/placement and assessed HU reproducibility.

Methods

Three non-radiologists independently identified the L1 and L4 vertebral body centroid and then placed varying size circular ROIs on axial and sagittal images of 30 clinical CT scans. A 200-mm² ROI location was varied left to right, anterior to posterior, and cranial to caudal. Intra- and inter-observer reliability was determined using intraclass correlation coefficients (ICC). ROI size and axial/sagittal HU comparison was performed by ANOVA and t-test. Precision of 200-mm

SUBMITTER: Sobecki JN 

PROVIDER: S-EPMC12296150 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature