Resting-State EEG Alpha Asymmetry as a Potential Marker of Clinical Features in Parkinson's Disease.

ABSTRACT: Background: Asymmetrical brain oscillations may be characteristic of Parkinson's disease (PD). We investigated differences in oscillation asymmetry between individuals with PD and healthy controls and explored associations between the asymmetry and clinical features. Methods: Clinical and resting-state EEG data from 37 patients and 24 controls were cross-sectionally analyzed. EEG asymmetry indices were calculated for the delta, theta, alpha, and beta frequencies in the frontal, central, and parietal regions. Independent t-tests and linear regression models were employed. Results: Patients exhibited lower alpha asymmetry than controls in the parietal region (t(59) = 2.12, p = 0.03). In the frontal alpha asymmetry models, there were associations with time since di

SUBMITTER: da Rocha TF 

PROVIDER: S-EPMC12296173 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature