A bioadhesive pacing lead for atraumatic cardiac monitoring and stimulation in rodent and porcine models.

ABSTRACT: Current clinically used electronic implants, including cardiac pacing leads for epicardial monitoring and stimulation of the heart, rely on surgical suturing or direct insertion of electrodes to the heart tissue. These approaches can cause tissue trauma during the implantation and retrieval of the pacing leads, with the potential for bleeding, tissue damage, and device failure. Here, we report a bioadhesive pacing lead that can directly interface with cardiac tissue through physical and covalent interactions to support minimally invasive adhesive implantation and gentle on-demand removal of the device with a detachment solution. We developed 3D-printable bioadhesive materials for customized fabrication of the device by graft-polymerizing polyacrylic acid on hydrophilic polyurethane and mix

SUBMITTER: Deng J 

PROVIDER: S-EPMC12296291 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature