Neonatal outcomes following previable rupture of membranes below 23 weeks' gestation.

ABSTRACT: This study aimed to provide institution-specific, up-to-date data to improve counseling for pregnant women experiencing preterm premature rupture of membranes (pPROM) before or at the limit of viability. We conducted a retrospective cohort study (2009-2022) of preterm infants with pPROM < 23 + 0 weeks' gestation who received active neonatal care. The primary outcomes were survival and survival without severe short-term morbidity (defined as IVH III, PVHI, cPVL, and/or ROP). Data from 109 patients with a median gestational age at pPROM of 21.6 weeks and a median gestational age at delivery of 25.4 weeks were analyzed. The overall survival rate was 69.7%, and survival without short-term severe morbidity was 51.4%. Both outcomes improved significantly with increasing gestational age at birth.

SUBMITTER: Grill A 

PROVIDER: S-EPMC12296744 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature