Risk Factors, Clinical Course, and Management of Delayed Perforation After Colorectal Endoscopic Submucosal Dissection: A Large-Scale Multicenter Study.

ABSTRACT:

Introduction

Delayed perforation (DP) remains a significant complication of colorectal endoscopic submucosal dissection (ESD). This study analyzed the risk factors, clinical course, and management for DP following colorectal ESD.

Methods

We retrospectively reviewed 4,632 consecutive colorectal ESD cases from 13 institutions between January 2006 and May 2024. DP cases were identified, and the incidence rate, along with patient/lesion characteristics (as tumor size, location, and severe fibrosis) were assessed. The clinical course, including onset timing, initial treatments, need for surgery, and risk factors were examined.

Results

DP occurred in 18 cases, with an incidence rate of 0.39% [95% confidence interval (CI): 0.24-0.62]. The mean tumor size was 49.7 ± 35.7 mm.

SUBMITTER: Yoshida N 

PROVIDER: S-EPMC12296770 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature