Neurofilament light chain reference values in serum and cerebrospinal fluid: a bi-compartmental analysis in neurological diseases.

ABSTRACT:

Background

Concentrations of neurofilament light chain (NfL), a neuroaxonal damage marker, increase with age. Therefore, age-dependent reference values are important in clinical practice. However, so far these have only been established with a bead-based system and age-dependent z-scores for CSF are missing. In addition, we here propose how the combined analysis of CSF and serum NfL could help in the discrimination between central (CNS) and peripheral nervous system (PNS) axonal degeneration.

Methods

For the calculation of age reference values, serum and CSF NfL concentrations from 1,514 control subjects, measured using the microfluidic Ella system, were applied.

Results

Age-dependent NfL levels were calculated with additive quantile regression and presented with perc

SUBMITTER: Halbgebauer S 

PROVIDER: S-EPMC12296792 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature