Opioidergic modulation of monetary incentive delay fMRI responses.

ABSTRACT:

Rationale

It is hypothesised that modulation of striatal dopaminergic signalling plays a key role in the rewarding effects of opioids. The monetary incentive delay (MID) task is a functional magnetic resonance imaging (fMRI) paradigm used to investigate striatal responses, which may reflect striatal dopamine release, during the anticipation of a financial reward.

Objectives

We hypothesised that fentanyl would modulate striatal MID task Blood Oxygenation Level Dependent (BOLD) responses, reflecting opioidergic modulation of striatal dopaminergic signalling.

Methods

24 right-handed males who undertook four MRI scanning sessions, during which they completed an MID task 15 min after receiving an intravenous infusion of either one of two doses of fentanyl (50 µg/70kg), nal

SUBMITTER: Turton S 

PROVIDER: S-EPMC12296811 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature