Systematic review and meta-analysis of photon radiotherapy versus proton beam therapy for pediatric rhabdomyosarcoma: TRP-rhabdomyosarcoma 2024.

ABSTRACT:

Background

Childhood cancer treatment has increasingly achieved favorable long-term survival rates, shifting focus toward reducing long-term comorbidities. Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue tumor, and radiation therapy is essential for its treatment. Proton beam therapy (PBT) is currently utilized due to its potential to reduce long-term complications; however, data on its impact on tumor prognosis remain limited.

Methods

We conducted a meta-analysis to evaluate whether differences in tumor prognosis exist based on radiation therapy modalities, such as photon radiotherapy (photon RT) and PBT, for pediatric parameningial RMS-only study (Group 2) and other pediatric RMS (Group 1). Studies published between 1990 and 2022 were included if they were

SUBMITTER: Fukushima H 

PROVIDER: S-EPMC12296975 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature