The network map of mucin 1 mediated signaling in cancer progression and immune modulation.

ABSTRACT: Mucin 1 (MUC1) is a type-I transmembrane glycoprotein, ranked as the second most promising cancer antigen for therapeutic development by the National Cancer Institute. Recently, MUC1 has gained significant attention as a therapeutic target in cancer immunotherapy. Thus, understanding MUC1-regulated signaling is essential for advancing therapeutic strategies. Since existing pathway repositories lack a comprehensive MUC1 signaling map, we constructed one by manually annotating experimentally validated signaling events from 115 articles following NetPath annotation criteria. Considering the topology of annotated molecules, a pathway map was developed using the PathVisio software. This pathway map is a valuable resource cataloguing 209 molecules and 690 signaling events, of which 395 events ar

SUBMITTER: Palollathil A 

PROVIDER: S-EPMC12297148 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature