Identification and validation of biomarkers associated with glycolysis in polycystic ovarian syndrome.

ABSTRACT: Polycystic ovary syndrome (PCOS), an endocrine disorder emerging in adolescence and reproductive years, has been linked to glycolysis in prior studies, though the precise mechanistic role of glycolysis in its pathogenesis remains unclear. Therefore, this study sought to identify glycolysis-related biomarkers in PCOS and elucidate their regulatory mechanisms to provide novel therapeutic strategies. Utilizing publicly available datasets, biomarkers were identified via differential analysis, various PPI algorithms, and validation of expression patterns. Subsequent analyses included functional enrichment, tissue and cell-specific expression profiling, m6A modification site prediction, compound screening, molecular network construction, and molecular docking. RT-qPCR was performed on clinical s

SUBMITTER: Zhu R 

PROVIDER: S-EPMC12297368 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature