Effects of inhaled nitric oxide on ventilation/perfusion mismatch assessed by electrical impedance tomography in patients with ARDS: a prospective observational study.

ABSTRACT:

Background

Our study aimed to assess the effects of inhaled nitric oxide (iNO) on ventilation/perfusion mismatch, and individual variability in patients with acute respiratory distress syndrome (ARDS) by electrical impedance tomography (EIT).

Methods

This single-center, prospective physiological study enrolled mechanically ventilated ARDS patients. All patients initially received 5 ppm iNO; responders (≥ 20% increase in PaO₂/FiO₂ at 30 min) maintained this dose, while non-responders had their dose doubled every 30 min, up to 40 ppm, until achieving a ≥ 20% improvement. The trial lasted 3 h. EIT data and clinical respiratory and hemodynamic parameters were collected at baseline (0 h), and at 30 min and 3 h after iNO initiation.

Results

At 30 min,

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12297762 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature