Accelerating Effects of Poloxamer and Its Structural Analogs on the Crystallization of Nitrendipine Polymorphs.

ABSTRACT: Background: Surfactants can be added into polymer-amorphous drug systems to further enhance solubility. However, this may cause amorphous drugs to become physically unstable, and the inherent mechanism at play here is not fully understood. Methods: We explored the effects of poloxamer, a poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) triblock copolymer surfactant, and its segments on the nucleation and growth kinetics of amorphous nitrendipine (NTP) from the melt through polarized light microscopy. The effects of poloxamer and structural analogs on the melting point and glass transition temperature were also investigated using differential scanning calorimetry. Results: The poloxamer and its structural analogs enhanced nucleation and g

SUBMITTER: Zhang J 

PROVIDER: S-EPMC12298067 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature