Advances in Genetic Risk Scores for Alzheimer's Disease and Dementia: A Systematic Review.

ABSTRACT:

Background

Research concerning the genetic risk for dementia has recently been headed towards new directions. Novel findings from genome-wide association studies have highlighted the association of Alzheimer's disease incidence with many gene polymorphisms, apart from the Apolipoprotein-E genotype. The identification of additional genetic risk factors has led to the construction of specific genetic risk scores for dementia, considering many different genetic factors and specific biological pathways related to Alzheimer's disease.

Methods

We conducted a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis method, summarizing existing data regarding genetic risk scores for Alzheimer's disease and dementia, in order to improve the c

SUBMITTER: Sampatakakis SN 

PROVIDER: S-EPMC12298128 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature