Vitamin D's Impact on Cancer Incidence and Mortality: A Systematic Review.

ABSTRACT: Background/Objectives: Adequate vitamin D levels are essential for various physiological functions, including cell growth, immune modulation, metabolic regulation, DNA repair, and overall health span. Despite its proven cost-effectiveness, widespread deficiency persists due to inadequate supplementation and limited sunlight exposure. Methods: This systematic review (SR) examines the relationship between vitamin D and the reduction of cancer risk and mortality, and the mechanisms involved in cancer prevention. This SR followed the PRISMA and PICOS guidelines and synthesized evidence from relevant studies. Results: Beyond genomic actions via calcitriol [1,25(OH)₂D]-receptor interactions, vitamin D exerts cancer-protective effects through mitigating inflammatio

SUBMITTER: Wimalawansa SJ 

PROVIDER: S-EPMC12298439 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature