Viremia Kinetics in Pigs Inoculated with Modified Live African Swine Fever Viruses.

ABSTRACT:

Background

African Swine Fever (ASF) is a viral hemorrhagic disease characterized by diverse clinical and pathological manifestations depending on the virulence of isolates/strains and the immunological status of pigs. The use of modified live viruses (MLVs) is currently the most common approach in developing vaccines against ASF. However, despite the availability of dozens of MLV candidates that meet basic safety and efficacy criteria-such as the absence of severe clinical signs and survival after challenge with a virulent strain-no broadly accepted vaccine has yet been developed. Here, we propose viremia testing as an essential criterion for evaluating candidate ASF vaccines, with levels exceeding 10⁴ HAD₅₀/TCID₅₀ and lasting longer than 21-28 day

SUBMITTER: Sereda A 

PROVIDER: S-EPMC12298559 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature