Characterization, Genomic Analysis and Application of Five Lytic Phages Against Carbapenem-Resistant <i>Pseudomonas aeruginosa</i>.

ABSTRACT: The high pathogenicity rate of carbapenem-resistant Pseudomonas aeruginosa (CRPA) has resulted in substantial economic losses for humans and the breeding industry. Consequently, there is an urgent need to develop new alternatives to mitigate antibiotic use. Phage therapy has demonstrated promising results in numerous studies. In this study, lytic phages targeting CRPA were isolated from feces and river water samples in Shandong, China. A total of 94 phage strains with CRPA as hosts were obtained, exhibiting lysis rates that ranged from 29% to 76% for P. aeruginosa derived from humans and different types of animals (n = 246). We further examined five representative phages, the host bacteria of which were CRPA from clinical patients and poultry, and these phages included two my

SUBMITTER: Zhang LP 

PROVIDER: S-EPMC12298563 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature