Metabolomic Profiling and Anti-<i>Helicobacter pylori</i> Activity of <i>Caulerpa lentillifera</i> (Sea Grape) Extract.

ABSTRACT: Helicobacter pylori is a gastric pathogen implicated in peptic ulcer disease and gastric cancer. The increasing prevalence of antibiotic-resistant strains underscores the urgent need for alternative therapeutic strategies. In this study, we investigated the chemical composition and antibacterial activity of an aqueous extract from Caulerpa lentillifera (sea grape), a farm-cultivated edible green seaweed collected from Krabi Province, Thailand. Ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) revealed that the extract was enriched in bioactive nucleosides and phenolic compounds. In vitro assays demonstrated dose-dependent inhibition of H. pylori growth following exposure to sea grape extract. Furthermore, untargeted intracellular metab

SUBMITTER: Thacharoen C 

PROVIDER: S-EPMC12298704 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature