Amikacin Coated 3D-Printed Metal Devices for Prevention of Postsurgical Infections (PSIs).

ABSTRACT: Background/Objectives: Personalized 3D-printed (3DP) metallic implants delivery systems are being explored to repair bone fractures, allowing the customization of medical implants that respond to individual patient needs, making it potentially more effective and of greater quality than mass-produced devices. However, challenges associated with postsurgical infections caused by bacterial adhesion remain a clinical issue. To address this, local antibiotic therapies are receiving extensive attention to minimize the risk of implant-related infections. This study investigated the use of amikacin (AMK), a broad-spectrum aminoglycoside antibiotic, incorporated onto 3D-printed 316L stainless steel implants using biodegradable polymer coatings of chitosan and poly lactic-co-glycolic acid (PL

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12298719 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature