RNA-Seq Analysis of Mouse Hepatocytes AML12 Exposed to Neodymium Nitrate.

ABSTRACT:

Objective

Neodymium nitrate (Nd(NO₃)₃) is widely used globally, raising concerns about its occupational and environmental safety. It enters the human body via the digestive system, accumulates in organs, and causes toxicity, including potential hepatotoxicity. However, the role of non-coding RNAs (ncRNAs) in Nd(NO₃)₃-induced liver injury remains unclear. This study aimed to identify key genes and regulatory pathways involved in Nd(NO₃)₃-induced hepatic injury using RNA sequencing (RNA-seq) and differential gene expression analysis.

Methods

Mouse hepatocytes (AML12 cells) were exposed to Nd(NO₃)₃, and RNA-seq was performed to analyze the expression profiles of miRNA, lncRNA, circRNA, and m

SUBMITTER: Wang N 

PROVIDER: S-EPMC12299013 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature