Challenges and Lessons Learned from a Field Trial on the Understanding of the Porcine Respiratory Disease Complex.

ABSTRACT:

Background/objectives

The porcine respiratory disease complex (PRDC) is a multifaceted, polymicrobial syndrome resulting from a combination of environmental stressors, primary infections (e.g., PRRSV) and secondary infectious agents (viruses and bacteria). PRDC causes severe lung pathology, leading to reduced performance, increased mortality rates, and higher production costs in the global pig industry. Our goal was to conduct a comprehensive study correlating both the anti-PRRSV immune response and 21 secondary infectious agents with PRDC severity.

Methods

To this end, PRRSV-negative weaners were vaccinated with a PRRSV-2 MLV and put into a farm with a history of PRDC. Subsequently, anti-PRRSV cellular and antibody responses were monitored pre-vaccination, at 28 days post v

SUBMITTER: Crisci E 

PROVIDER: S-EPMC12299284 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature